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what would you consider the lowest hanging fruit from a cost synergy standpoint and any additional color you could provide on the rate in which you expect to realize these synergies
which areas were most surprising versus your internal expectations
how does TAS continue to earn through this environment? Is the real-world evidence strength and other areas of strength within TAS offsetting any weakness than any of the other subsegments
what are you seeing as a bar for what you would want to see to bring this forward from an efficacy or safety perspective