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Obviously, you raised the guide there. Should we think about that being primarily driven by U.S. or OUS
Wanted to get a sense understanding of your expectations and flexibility, if need be to take actions outside the US
Are you taking actions or advocating either on your own or in conjunction with peers to address persistent unlawful compounding?
can you address those discussions and say definitively, whether you've gone back and added more patients since enrollment was completed
IP is under attack across the industry from multiple sources, but most notably compounding
the extent to which uncertainty around tariffs, FDA, drug pricing environment are sort of stage gates
Is it fair to assume those comments are anchoring on aperture adherence around 50% still
we've seen pretty volatile scripts over here the past couple of weeks. And I guess my question is, are the TRx that we're seeing reflective of what you're seeing
your continued confidence on anito-cel approvability based on a single-arm study
there have been a number of cuts across HHS, CDC to start the year across various teams, divisions. Raising uncertainty around potential disruptions
anything you can share there around if you think potential MFN legislation is a priority or possibility in the coming balance of the year?
can this reach your targets if it ultimately requires every 4-week dosing? Or put differently, are there reasons you have conviction
how does Merck think about the importance and speed it may need to pursue combinations on the back of those data
I wanted to ask you around your confidence in ultimately hitting on OS in the 022 study
should investors have any expectation around a comprehensive deal that addresses the President's objectives across MFN and tariffs
Is Vyndaqel U.S. growth behind us?
should we think about that as more of a convenience play sort of with the co-administration
you framed it remaining committing to that funding until the end of the year, which I guess sort of alluded
can you help us think about if there's been -- if you've delivered any matching funds yet
this is your fourth CRL and as well as a delay in the past sort of 12 months