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how we should think about pricing for the COVID vaccine in the U.S. this year? And what your expectations are for net price
if you needed to or wanted to reduce R&D spend further, how much flexibility is there on the expense structure there for, say, further cuts in the 2026 time frame
On the clinical hold on Norovirus, can you give any more detail around sort of this, why one case of GBS prompted the clinical hold