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are you willing to start the pivotal Phase 3 trial with just target engagement data in hand? Are you going to wait before doing so until you see a clear functional signal there
CMS is obviously proposing to cut reimbursement for PYP scintigraphy, I think, by 57% from $1,300 all the way down to $500
it feels to me that this guide has still a good degree of conservatism in it, especially given that you're going to start selling this drug
it sounds like step edits are likely going to be implemented for commercial patients
Jeff, how should we think about gross margin here going forward
Can you tell us more about what is next for INVELTRA? Not only in terms of the opportunity you get once you move to the front lines
What's Amgen's appetite to augment your current offering vis-a-vis by adding an oral small molecule via either BD or organic discovery?
can you just walk us through why the legal team deemed the additional $1.3 billion charge on 1498 is not probable
can you just talk about what gives you confidence that you can reiterate your cash breakeven guide for 2028
are you actively spending time in China and if so, are you just looking at strengthening your mRNA capabilities? Or are you open to other modalities
are you actively spending time in China and if so, are you just looking at strengthening your mRNA capabilities? Or are you open to other modalities
can you just talk about what gives you confidence that you can reiterate your cash breakeven guide for 2028
have you talked to either the President, RFK or any of the representative this time around? If so, what has been the message